Antioxidants
such as Vitamin E, Vitamin C, zinc, copper, and manganese assist
in the reduction of free radicals, thus reducing inflammation
and subsequent cellular damage.
Reducing oxidative stress may
reduce Hypothalamic – Pituitary – Adrenal stimulation
of elevated cortisol.
Zinc, copper and manganese enhance the production of the antioxidant
enzyme super oxide dismutase (SOD). This enzyme is responsible
for quenching the super oxide radical often elevated in patients
with joint/connective tissue inflammation. Vitamin E protects
against lipid peroxidation. Vitamin C has antioxidant properties.
It helps preserve intracellular reduced glutathione levels,
may modulate prostaglandin synthesis and helps regenerate Vitamin
E’s antioxidant capacity.
B Vitamins can
support a healthy nervous system, improve blood sugar control
and contribute (along with antioxidants and minerals) to a healthy
phase I/phase II liver detoxification process. These potential
functions of B Vitamins contribute to a healthy stress response
and may reduce the tendency for excessive HPA activity. Pantothenic
Acid along with Vitamin C have been used historically as anti-stress
adrenal support vitamins.
L-Tyrosine is
utilized in the production of thyroid hormones and norepinephrine/epinephrine
(noradrenaline/adrenaline) adrenal hormones and CNS neurotransmitters.
Botanicals
Basil (Ocimum basilicum) can support healthy digestion and appetite.
Ginkgo’s properties of anti-oxidant, cell membrane stabilizing,
circulation enhancing, improved hypoxic tolerance, improved
glucose utilization can reduce the effects of stress. Gotu Kola
(Centella asiatica) may improve circulation especially in persons
suffering from venous insufficiency. Its historical uses also
include support for mental and physical exhaustion. Commiphora
mukul has antioxidant, anti-inflammatory properties. It can
support healthy circulation by assisting in regulating ideal
cholesterol levels. Schizandra has been used traditionally to
combat fatigue and enhance the immune system. Tinospora cordifola
has been shown to have hepatoprotectant and immunomodulatory
properties.
References:
1. PDR for Nutritional Supplements, 1st Ed. Medical Economics/Thomson
Healthcare. 2001.
2. Murray MT. Encyclopedia of Nutritional Supplements, The
Essential Guide for Improving Your Health Naturally. Prima Publishing.
1996.
3. Werbach MR. Nutritional Influences on Illness: A sourcebook
of clinical research, 2nd Edition. Third Line Press, Tarzana,
CA. 1993.
4. Werbach MR, Murray MT. Botanical Influences on Illness:
A sourcebook of clinical research, 2nd Ed. Third Line Press,
Tarzana, CA. 2000.
5. PDR for Herbal Medicines, 1st Ed, Medical Economics/Thomson
Healthcare. 1998.
6. Pfeiffer C. Mental and Elemental Nutrients. Keats Pub, New
Canaan, CT, 1975.
7. Prasad A. Clinical, biochemical and nutritional spectrum
of zinc deficiency in human subjects: An update. Nutrition Reviews
41, 197-208, 1983
8. Goldenber RL, et al. The effect of zinc supplementation
on pregnancy outcome. JAMA 274, 463-468, 1995.
9. Dardenna M, et al. Contribution of zinc and other metals
to the biological activity of the serum thymic factor. Proc
Natl Acad Sci 79, 5370-5373, 1982.
10. Netter A, et al. Effect of zinc administration on plasma
testosterone, dihydrotestosterone and sperm count. Arch Androl
7, 69-73, 1981.
11. Newsome DA, et al. Oral zinc in macular degeneration. Arch
Ophthalmol 106, 192-198, 1988.
12. Constantinidis J. The hypothesis of zinc deficiency in
the pathogenesis of neurofibrillary tangles. Med Hypoth 35;
319-323, 1991.
13. Constantinidis J. Alzheimer’s disease and the zinc
theory. Encephale Jul-Aug;16(4):231-9, 1990.
14. Brewer GJ. Practical recommendations and new therapies
for Wilson’s disease. Drugs 50, 240-249, 1995.
15. Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter
precursor, reduces environmental stress in humans. Brain Res
Bull. 22: 759-762, 1989.
16. Young SN. Behavioral effects of dietary neurotransmitter
precursors: basic and clinical aspects. Neurosci Biobehav Rev.
20:313-323, 1996.
17. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora
cordifolia. J Ethnopharmacol 58(2):89-95, 1997.
