Calcium Citrate/Malate
is considered to be the most soluble and bioavailable form of
calcium available. It has been reported to be six times more
soluble than either calcium citrate or calcium malate alone.
Supplementation reduces risk of post-menopausal bone loss, osteoporosis,
and fracture.
Magnesium
OsteoGenesis™ magnesium is supplied in both the glycinate
and citrate/malate forms. In OsteoGenesis E.S.™ magnesium
is provided in the citrate form only. Both products supply highly
bioavailable forms of magnesium. Magnesium has been shown to
regulate active calcium transport and optimize bone response
when taken with calcium. Studies have shown that magnesium significantly
increases bone density in menopausal women. Magnesium acts as
a cofactor in vitamin D hormone activation, and in alkaline
phosphatase enzyme formation of bone crystals. Magnesium also
contributes to parathyroid hormone regulation.
Vitamin D3 (Cholecalciferol)
is the natural form of Vitamin D. It has several beneficial
actions on bone metabolism. It is essential in prevention of
fractures resulting from osteoporosis and helps prevent bone
loss in elderly women. Vitamin D enhances calcium transport
across intestinal mucosal cells and enhances osteoblastic bone
matrix production. It enhances production of the pro-bone hormone
osteocalcin and has regulatory effects on alkaline phosphatase
enzyme and collagen protein synthesis. In OsteoGenesis™
and OsteoGenesis E.S.™ we do not attempt to supply 100%
of the RDA of Vitamin D. Many patients take a multivitamin/mineral
formula that also contains Vitamin D. UltraGenesis™ Multivitamin/mineral
with or without iron would be an excellent choice.
Boron improves
the metabolism of calcium, phosphorus, and magnesium. It reduces
the loss of these minerals through the urine. Boron influences
the synthesis of estrogen, Vitamin D, and other steroidal hormones,
extending their half-life by protecting them from rapid breakdown.
Boron has been shown to increase the tensile strength of connective
tissue in bone.
Horsetail (Equisetum arvense)
is a natural organic source of water-soluble colloidal silica.
Silica strengthens bone matrix connective tissue by enhancing
cross-linking of collagen strands. Silica actually concentrates
at calcification points of growing bone. Animals fed a silica
deficient diet show bone developmental abnormalities.
Zinc, Copper, Manganese, Vanadium
and Vitamin C assist in the production of type
1 collagen essential for healthy bone remineralization.
References:
1. Joiner-Bey, Natural Bone Health Agents. Monograph. 2000.
2. Dawson-Hughs B, et. al. A controlled trial of the effect
of calcium supplementation on bone density in postmenopausal
women. The New England Journal of Medicine 1990;323(13):878-883.
3. Pines A, Raafat H, Lynn AH, Whittington J. Clinical trial
of microcrystalline hydroxyapatite compound (‘Ossopan’)
in the prevention of osteoporosis due to corticosteriod therapy.
Curr Med Res Opin 1984;8(10):734-742.
4. Anusdei D, et al. A double blind, placebo-controlled trial
of ipriflavone for prevention of postmenopausal spinal bone
loss. Calcif Tissue Int 1997 Aug;61(2):142-7.
5. Gennari C, et. al. Effect of ipriflavone – a synthetic
derivative of natural isoflavones – on bone mass loss
in the early years after menopause. Menopause 1998 Spring; 5(1):
9-15.
6. Nielson FH, et. al. Effect of dietary boron on mineral, estrogen,
and testosterone metabolism in postmenopausal women. FASEB J
1987 Nov;1(5):394-397.
7. Ooms ME, et. al. Prevention of bone loss by vitamin D supplementation
in elderly women: a randomized double-blind trial. J Clin Endocrinol
Metab 1995 Apr; 80(4): 1052-8.
